UG Researcher Nears Blueprint for Predicting Viral Severity

Introduction

A groundbreaking study at the University of Ghana (UG) is on the verge of transforming global pandemic preparedness. Led by Maame Ekua Acquah, a PhD candidate at the West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), this research aims to predict viral severity by examining the role of human genes. The findings could revolutionize how nations respond to fast-spreading viral threats like COVID-19.

Key Points

Research Focus: Investigating the role of human genes, particularly ACE2, in determining viral severity.
Study Scope: 1,243 biological samples collected from urban and peri-urban regions in Ghana.
Potential Impact: Predicting vulnerability to viral infections, enhancing public health planning and response strategies.
Recognition: Acquah honored among 30 young scientists in the 2025 L’Oréal-UNESCO For Women in Science Sub-Saharan Africa Awards.

Background

The Role of ACE2 in Viral Infections

The Angiotensin Converting Enzyme 2 (ACE2) is a critical cell “doorway” that many viruses, including SARS-CoV-2, use to enter the human body. Acquah’s research seeks to understand how variations in ACE2 behavior among different individuals affect the severity of viral infections.

Study Methodology

Acquah’s study, titled ‘Unlocking Pandemic Prevention,’ began three years ago and is scheduled for completion in July 2026. The research involves analyzing genetic variations across populations to determine how socioeconomic and environmental factors influence ACE2 expression.

Analysis

Genetic Variations and Viral Severity

By mapping genetic variations, Acquah aims to identify whether differences in ACE2 expression can predict who is most at risk during viral outbreaks. This information could be crucial for public health planning, allowing health systems to prioritize vulnerable populations and customize treatment strategies.

Global Implications

The findings from this study could have far-reaching implications. Understanding how human genes shape the evolution of viruses like COVID-19 can guide better ways of preventing or protecting against future pandemics. This research is particularly relevant as the world anticipates the next pandemic, which is seen as an inevitability rather than a possibility.

Practical Advice

Public Health Planning

Health systems can use the findings from Acquah’s research to enhance their preparedness for future pandemics. By identifying vulnerable populations based on genetic predisposition, public health officials can prioritize resource allocation and customize treatment strategies.

Community Engagement

Acquah’s approach to sampling, which involved community engagements and health outreach programs, highlights the importance of building trust and increasing participation in medical research. This method can be replicated in other studies to ensure diverse and representative data collection.

FAQ

What is the focus of Acquah’s research?

Acquah’s research focuses on understanding how human genes, particularly ACE2, influence the severity of viral infections.

How can the findings from this study be used?

The findings can be used to predict vulnerability to viral infections, enhance public health planning, and customize treatment strategies.

What recognition has Acquah received?

Acquah has been honored among 30 young scientists in the 2025 L’Oréal-UNESCO For Women in Science Sub-Saharan Africa Awards.

Conclusion

Maame Ekua Acquah’s research at the University of Ghana is poised to make a significant impact on global pandemic preparedness. By understanding the role of human genes in viral severity, her findings could revolutionize how nations respond to fast-spreading viral threats. This study not only highlights the importance of genetic research but also underscores the need for diverse and representative data collection in medical research.